Preferential patterns of myocardial iron deposition by multislice multiecho T2* CMR in thalassemia major patients
نویسندگان
چکیده
A. Meloni, V. Positano, A. Pepe, P. Pepe, M. C. Dell'Amico, C. Salvatori, P. Keilberg, G. Valeri, E. Cracolici, P. Bitti, A. Zuccarelli, M. F. Santarelli, and M. Lombardi MRI Lab, “G. Monasterio Foundation” and Institute of Clinical Physiology, CNR, Pisa, Italy, Azienda Ospedaliero-Universitaria Ospedali Riuniti "Umberto I-LancisiSalesi", Ancona, Italy, Policlinico "Paolo Giaccone", Palermo, Italy, Dipartimento dei Servizi P. O. San Francesco, Nuoro, Italy, Centro trasfusionale e di microcitemia Ospedale civile, Olbia, Italy
منابع مشابه
Different patterns of myocardial iron overload by T2* Cardiovascular MR as markers of risk for cardiac complication in thalassemia major
Background Cardiac complications mainly related to myocardial iron overload (MIO) remain the main cause of morbidity and mortality in thalassemia major (TM). Thalassemia cardiomyopathy is treatable and partly reversible if appropriate chelation therapy is instituted in time. The validated multislice multiecho T2* Cardiovascular Magnetic Resonance (CMR) technique has permitted to quantify segmen...
متن کاملMultislice Multiecho T2* MRI assessment of regional pancreatic iron overload and correlation with cardiac biventricular function and myocardial iron overload in thalassemia major patients
Introduction: Thalassemia major (TM) patients require lifelong iron load monitoring to assess the effectiveness of chelation therapies. Multiecho T2* MRI is a well established technique for heart and liver iron overload assessment [1]. There are few reports on the use of MRI to study iron deposits in the pancreas. The aims of this study were to describe the T2* values of the pancreas in patient...
متن کاملMyocardial iron overload in thalassaemia major. How early to check?
The age at which it is necessary to start Cardiovascular Magnetic Resonance (CMR) T2* screening in thalassaemia major (TM) is still uncertain. To clarify this point, we evaluated the prevalence of myocardial iron overload (MIO), function and fibrosis by CMR in TM patients younger than 10 years. We retrospectively selected 35 TM patients enrolled in the Myocardial Iron Overload in Thalassaemia n...
متن کاملMulticenter validation of the magnetic resonance T2* technique for segmental and global quantification of myocardial iron.
PURPOSE To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2(*) technique for global and segmental measurement of iron overload in thalassemia patients. MATERIALS AND METHODS Multiecho T2(*) sequences were installed on six MRI scanners. Five healthy subjects (n = 30) were scanned at each site; five thalassemia major (TM) patients were scanned at the re...
متن کاملMyocardial iron overload in thalassemia major. How early to check?
Methods From the 2171 patients enrolled in the MIOT (Myocardial Iron Overload in Thalassemia) network, we retrospectively selected the 35 TM patients aged less than 10 years who had undergone at least one MRI scan. Myocardial iron overload (MIO) was measured by T2* multislice multiecho technique. Biventricular function parameters were quantitatively evaluated in a standard way by cine images. T...
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